Clinical Obstetrics and GynecologyManagement of Preinvasive LesionsPATRONO, MARIA G. MD*; CORZO, CAMILA MD†; INIESTA, MARIA MD†; RAMIREZ, PEDRO T. MD†Author Information *Department of Gynecology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina †Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas The authors declare that they have nothing to disclose. Correspondence: Pedro T. Ramirez, MD, Department of Gynecologic Oncology and Reproductive Medicine, Unit 1362, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX. E-mail: [email protected] Clinical Obstetrics and Gynecology: December 2017 - Volume 60 - Issue 4 - p 771-779 doi: 10.1097/GRF.0000000000000316 Buy Metrics Abstract Serous tubal intraepithelial carcinoma is considered the precursor lesion of high-grade serous carcinoma, and found in both low-risk and high-risk populations. Isolated serous tubal intraepithelial carcinomas in patients with BRCA1/2 mutations are detected in ∼2% of patients undergoing risk-reducing bilateral salpingo-oophorectomy and even with removal of the tubes and ovaries the rate of developing primary peritoneal carcinoma following remains up to 7.5%. Postoperative recommendations after finding incidental STICs remain unclear and surgical staging, adjuvant chemotherapy, or observation have been proposed. Discovery of STIC should prompt consideration of hereditary cancer program referral for BRCA1/2 mutation screening. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.