Trends in Breast Cancer ManagementBreast Cancer: Genetics and Risk AssessmentTEJADA-BERGÉS, TREVOR MD, MScAuthor Information Lifehouse Gynaecological Oncology Group, The University of Sydney, Sydney, Australia The author declares that they have nothing to disclose. Correspondence: Trevor Tejada-Bergés, MD, MSc, Lifehouse Gynaecological Oncology Group, The University of Sydney, Sydney, Australia. E-mail: [email protected] Clinical Obstetrics and Gynecology: December 2016 - Volume 59 - Issue 4 - p 673-687 doi: 10.1097/GRF.0000000000000236 Buy Metrics Abstract As health care providers, we play a crucial role in the assessment of a patient’s risk for hereditary breast cancer syndromes. The panorama of genetic assessment and testing has evolved dramatically since the identification of the BRCA genes. Next-generation sequencing technology has facilitated the development of multigene panels, but 1 consequence has been an increased identification of pathogenic variants at odds with a family history as well as variants of uncertain significance for which treatment guidelines are not defined. Progress in this field requires close collaboration between patients and clinicians with a thorough understanding in cancer genetics. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.