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Immunologic Abnormalities, Treatments, and Recurrent Pregnancy Loss: What Is Real and What Is Not?

WANG, NATHALIE F. MD; KOLTE, ASTRID M. MD; LARSEN, ELISABETH C. MD, PhD; NIELSEN, HENRIETTE S. MD, DMSc; CHRISTIANSEN, OLE B. MD, DMSc

Clinical Obstetrics and Gynecology: September 2016 - Volume 59 - Issue 3 - p 509–523
doi: 10.1097/GRF.0000000000000215
Status of Recurrent Pregnancy Loss
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Recurrent pregnancy loss, depending on the definition, affects 1% to 3% of women aiming to have a child. Little is known about the direct causes of recurrent pregnancy loss, and the condition is considered to have a multifactorial and complex pathogenesis. The aim of this review was to summarize the evaluation and the management of the condition with specific emphasis on immunologic biomarkers identified as risk factors as well as current immunologic treatment options. The review also highlights and discusses areas in need of further research.

*Recurrent Pregnancy Loss Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Department of Obstetrics and Gynecology, Aalborg University Hospital and Clinical Institute, Aalborg University, Aalborg, Denmark

The authors declare that they have no disclosures.

Correspondence: Ole B. Christiansen, MD, DMSc, Recurrent Pregnancy Loss Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. E-mail: olbc@rn.dk

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.