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Genotype and Phenotype


Clinical Obstetrics and Gynecology: March 2016 - Volume 59 - Issue 1 - p 25–29
doi: 10.1097/GRF.0000000000000177
Modern Management of Fibroids

Fibroids represent a major public health care problem as the most prevalent pelvic tumors in women of reproductive age and as the leading cause of gynecologic surgeries in the United States. The recent advances in the genomic technologies including genome-wide association studies and high-throughput sequencing provide insight into their pathogenesis and molecular classification. Understanding the molecular basis of fibroids may facilitate development of effective targeted treatment options of this very common disease.

*Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital

Department of Pathology, Massachusetts General Hospital

Harvard Medical School, Boston, Massachusetts

The author declares that there is nothing to disclose.

Correspondence: Zehra Ordulu, MD, Harvard Medical School, Massachusetts General Hospital, Warren Building 225, 55 Fruit Street, Boston, MA 02114. E-mail:

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.