Ambulatory Obstetric CarePrevention and Treatment of Venous Thromboembolism in PregnancyJAMES, ANDRA H. MD, MPHAuthor Information Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University Medical Center, Durham, North Carolina Dr James has received research funding from Grifols. Correspondence: Andra H. James, MD, MPH, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Virginia, P.O. Box 800712, Charlottesville, VA 22908. E-mail: firstname.lastname@example.org Clinical Obstetrics and Gynecology: September 2012 - Volume 55 - Issue 3 - p 774-787 doi: 10.1097/GRF.0b013e31825cfe7b Buy Metrics Abstract During pregnancy, women have a 4- to 5-fold increased risk of thromboembolism. Candidates for anticoagulation in pregnancy include women with current thrombosis, a history of thrombosis, risk factors for postpartum thrombosis, and some women with thrombophilia and a history of poor pregnancy outcome. Although, there are no large trials of anticoagulants in pregnancy and recommendations for their use are based on case series and the opinion of experts, observational studies demonstrate the benefit of heparins in reducing the risk of recurrent thromboembolism in pregnancy. A practical approach to the prevention and treatment of thromboembolism in pregnancy is outlined. © 2012 Lippincott Williams & Wilkins, Inc.