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Vaccines in Pregnant Women and Research Initiatives


Clinical Obstetrics and Gynecology: June 2012 - Volume 55 - Issue 2 - p 474–486
doi: 10.1097/GRF.0b013e31824f3acb
Prevention of Infection in the Obstetric Patient

Successful maternal immunization requires consideration of maternal and infant disease burden, biological factors affecting immune response and placental transport of antibodies, optimal timing of immunization, safety and acceptability. Tetanus, inactivated influenza and acellular pertussis vaccines are recommended during pregnancy; others are recommended when maternal risk of infection is high. The development of new conjugate vaccines for use in adults may reduce global maternal and infant disease burden. Maternal immunization against group B streptococcus is projected to be superior to current preventative strategies in decreasing disease. Further evaluation of maternal immunization strategies to prevent maternal and infant infections is needed.

Department of Pediatrics, Baylor College of Medicine, and Center for Vaccine Awareness and Research, Texas Children’s Hospital, Houston, Texas

Disclosure: Dr Healy receives research grants from Sanofi Pasteur and Novartis Vaccines and Diagnostics and serves on an advisory board for Novartis Vaccines.

Correspondence: C. Mary Healy, MD, 1102 Bates St. Suite 1120, Houston, TX. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.