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Thyroid Autoantibodies and Pregnancy Outcomes


Clinical Obstetrics and Gynecology: September 2011 - Volume 54 - Issue 3 - p 499–505
doi: 10.1097/GRF.0b013e31822730b9
Thyroid Disease in Pregnancy

Autoimmune thyroid disease has been associated with several adverse pregnancy outcomes. Increased risk of spontaneous miscarriage and placental abruption in women with thyroid antibodies has been confirmed in multiple studies. However, benefit of intervention and treatment of autoimmune thyroid disease in otherwise euthyroid pregnant women has not been sufficiently studied. The data on the association of thyroid antibodies and recurrent pregnancy loss or preterm birth are conflicting and a statistically significant association has not been shown in large studies. At present time, routine screening and treatment of autoimmune thyroid disease in euthyroid pregnant women is not warranted.

Disclosure: None.

Correspondence: Mina Abbassi-Ghanavati, MD, Suite 320, Lewisville, TX. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.