Screening for Thyroid Disease During PregnancyMILLER, EMILY S. MD, MPH; GROBMAN, WILLIAM A. MD, MBAClinical Obstetrics and Gynecology: September 2011 - Volume 54 - Issue 3 - p 471–477 doi: 10.1097/GRF.0b013e3182272ebf Thyroid Disease in Pregnancy Abstract Author Information Overt thyroid disease is a well-established risk factor for adverse pregnancy and perinatal outcomes. Whether or not subclinical thyroid dysfunction carries these same risks has been a matter of controversy. There is inconsistent evidence on the association of subclinical thyroid dysfunction (ie, subclinical hypothyroidism or isolated hypothyroxinemia) with a woman's pregnancy outcome or the cognitive development of her offspring and there are no interventional trials that have shown that women with subclinical hypothyroidism who are treated have improved outcomes. Until such data are available, it is premature to recommend universal screening for thyroid disease in pregnancy or treatment of women who have subclinical thyroid dysfunction. Northwestern University, Chicago, Illinois Disclosure: None. Correspondence: Emily S. Miller, MD, MPH, Northwestern University, 250 E Superior, Suite 05-2177, Chicago, IL 60611. E-mail: firstname.lastname@example.org © 2011 Lippincott Williams & Wilkins, Inc.