Uterine CarcinosarcomaEL-NASHAR, SHERIF A. MBBCh, MS; MARIANI, ANDREA MDClinical Obstetrics and Gynecology: June 2011 - Volume 54 - Issue 2 - p 292–304 doi: 10.1097/GRF.0b013e31821ac635 Endometrial Cancer Abstract Author Information Carcinosarcoma is a rare but highly aggressive uterine malignancy. Pathologically, carcinosarcoma is a biphasic neoplasm composed of a mixture of malignant epithelial and mesenchymal components. A comprehensive approach for management is recommended with complete surgical staging to assess tumor dissemination followed by multimodal therapy with combinations of external beam irradiation or vaginal brachytherapy and systematic chemotherapy in patients with both early and advanced stage disease. Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota The authors have no conflict of interest to disclose. Correspondence: Andrea Mariani, MD, Division of Gynecology, Mayo Clinic, Rochester, MN. e-mail: firstname.lastname@example.org © 2011 Lippincott Williams & Wilkins, Inc.