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Impact of Preterm PROM and its Complications on Long-term Infant Outcomes


Clinical Obstetrics and Gynecology: June 2011 - Volume 54 - Issue 2 - p 358–369
doi: 10.1097/GRF.0b013e318217ee18
Preterm Premature Rupture Of The Membranes

There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.

Department of Obstetrics and Gynecology at the University of Utah, Salt Lake City, Utah

Correspondence: Erin A. S. Clark, MD, University of Utah School of Medicine, Suite 2B200, 30 N 1900 E, Salt Lake City, UT. e-mail:

© 2011 Lippincott Williams & Wilkins, Inc.