Adjuvant Treatment for Early-stage Endometrial CancerZIGHELBOIM, ISRAEL MD; POWELL, MATTHEW A. MDClinical Obstetrics and Gynecology: June 2011 - Volume 54 - Issue 2 - p 245–255 doi: 10.1097/GRF.0b013e318218c5b8 Endometrial Cancer Abstract Author Information A subgroup of endometrial cancer patients with early-stage disease will progress or eventually present with recurrent disease. Multiple risk stratification strategies have been attempted to direct adjuvant therapeutic interventions. Radiation has been the most common form of adjuvant therapy offered to these patients. Unfortunately, its use has not translated into survival improvements. There is growing evidence supporting the use of adjuvant chemotherapy and multimodal interventions for patients with endometrial cancer. This review focuses on the role of adjuvant therapies for patients with early-stage disease with emphasis on future directions for risk stratification and personalized treatment. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri Correspondence: Israel Zighelboim, MD, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, Box 8064. St Louis, MO 63110. e-mail: firstname.lastname@example.org © 2011 Lippincott Williams & Wilkins, Inc.