Postpartum Hemorrhage: Evidence-based Medical Interventions for Prevention and TreatmentRAJAN, PRIYA V. MD; WING, DEBORAH A. MDClinical Obstetrics and Gynecology: March 2010 - Volume 53 - Issue 1 - p 165-181 doi: 10.1097/GRF.0b013e3181ce0965 Postpartum Hemorrhage Abstract Author InformationAuthors Article MetricsMetrics Postpartum hemorrhage (PPH) remains a significant contributor to maternal morbidity and mortality throughout the world. The majority of research on this topic has focused on efforts to prevent PPH. Sound data exist that active management of the third stage of labor can reduce the occurrence of PPH. Although there remains debate regarding the optimal protocol for active management, it appears at this time that oxytocin is the preferable uterotonic to use. Misoprostol may be a reasonable option where parenteral administration of an uterotonic is not feasible. There is little evidence to guide treatment decisions should PPH occur. Maternal-Fetal Medicine, Carolinas Medical Center, University of California, Irvine Correspondence: Priya V. Rajan, MD, Maternal-Fetal Medicine, Carolinas Medical Center, P. O. Box 32861, Charlotte, NC 28232. E-mail: firstname.lastname@example.orgNo financial support was received for this report. © 2010 Lippincott Williams & Wilkins, Inc.