Pregnancy TerminationMedication AbortionBARTZ, DEBORAH MD, MPH; GOLDBERG, ALISA MD, MPHAuthor Information Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Brigham and Women's Hospital, Planned Parenthood League of Massachusetts, Boston, Massachusetts Funding Disclosures: None. Correspondence: Deborah Bartz, MD, MPH, Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Brigham and Women's Hospital, Planned Parenthood League of Massachusetts, Boston, MA. E-mail: firstname.lastname@example.org Clinical Obstetrics and Gynecology: June 2009 - Volume 52 - Issue 2 - p 140-150 doi: 10.1097/GRF.0b013e3181a2b026 Buy SDC Metrics Abstract Medical methods for pregnancy termination in early gestation offer women an alternative to surgical evacuation and have the potential to improve access globally to safe abortion. Several drug regimens are used with varying efficacy including mifepristone plus misoprostol, misoprostol alone, and methotrexate plus misoprostol. Where available, a mifepristone plus misoprostol regimen is most frequently used and is highly effective for early abortion. We review these drug regimens along with clinical practice recommendations including patient counseling and selection, regimen administration location, expected side effects, and follow-up procedures. Overall, women who choose medical abortion report high levels of satisfaction. © 2009 Lippincott Williams & Wilkins, Inc.