Evidence-Based Approach to MenopauseSymptoms of Menopause: Hot FlushesSANTORO, NANETTE, MDAuthor Information Division of Reproductive Endocrinology, Albert Einstein College of Medicine, Bronx, New York Correspondence: Nanette Santoro, MD, Division of Reproductive Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. E-mail: firstname.lastname@example.org Clinical Obstetrics and Gynecology: September 2008 - Volume 51 - Issue 3 - p 539-548 doi: 10.1097/GRF.0b013e31818093f6 Buy Metrics Abstract Vasomotor symptoms (VMSs) are highly prevalent during the peri- and early postmenopause. They constitute a major driver for patient self-referral for medical care. Although most women will experience an abatement of their VMS by 5 years after their final menses, women with early or surgical menopause may have worse or more persistent symptoms, and up to 16% of naturally menopausal women continue to experience VMS well after their menopause is past. Although estrogen is the most effective known therapy, it is neither appropriate nor desirable for every symptomatic woman, and nonhormonal treatments such as gabapentin, selective serotonin reuptake inhibitors/selective norepinephrine reuptake inhibitors drugs, and the antihypertensives clonidine and alphamethyldopa may be helpful for some women. There is mounting evidence to support the ineffectiveness of many proposed complementary and alternative modalities. This review will highlight the natural history of VMS and the current medical evidence supporting various treatments. © 2008 Lippincott Williams & Wilkins, Inc.