Evidence-Based Approach to MenopauseHormone Therapy and StrokeBIRGE, STANLEY J., MDAuthor Information Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri Correspondence: Stanley J. Birge, MD, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 4488 Forest Park Blvd, St Louis, MO 63108. E-mail: SBirge@DOM.wustl.edu Clinical Obstetrics and Gynecology: September 2008 - Volume 51 - Issue 3 - p 581-591 doi: 10.1097/GRF.0b013e318181df30 Buy Metrics Abstract Available biochemical and clinical data are sufficiently compelling to recommend low dose or transdermal hormone therapy for the management of menopausal symptoms when possible. Women initiating low dose or transdermal hormone therapy are not at increased risk of cardiovascular disease, stroke, venous thrombotic disease, and breast cancer. Evidence suggests that these outcomes are favorably affected by low-dose hormone therapy and persist with continuation of therapy. © 2008 Lippincott Williams & Wilkins, Inc.