Current Concepts in Prenatal GeneticsThe Use of Prenatal Ultrasound for the Detection of Fetal AneuploidyHOLMGREN, CALLA MD*; LACOURSIERE, DAPHNE YVETTE MD, MPH† Author Information *Divison of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington †Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah Correspondence: Calla Holmgren, MD, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, PO Box 356460, Seattle, WA. E-mail: [email protected] Clinical Obstetrics and Gynecology 51(1):p 48-61, March 2008. | DOI: 10.1097/GRF.0b013e31816163e3 Buy Metrics Abstract Ultrasound is a noninvasive tool for early evaluation of the fetus and intrauterine environment. Its limitations include the lack of standardization of evaluation that patients receive, as well as varying sonologist's experience and equipment. Further, many fetuses with aneuploidy will not demonstrate significant sonographic findings, making detection limited. With regard to aneuploidy screening, its utility is improved when used in conjunction with analyte screening. Early recognition of fetal compromise allows families time for preparation and informed management of the gestation. © 2008 Lippincott Williams & Wilkins, Inc.