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From Educated Guess to Accepted Practice: The Use of Oral Antidiabetic Agents in Pregnancy


Clinical Obstetrics and Gynecology: December 2007 - Volume 50 - Issue 4 - p 959-971
doi: 10.1097/GRF.0b013e31815a55f3
Diabetes Mellitus in Pregnancy

When pharmacologic therapy is required, oral antidiabetic agents have been almost universally endorsed as first line drugs in the treatment of gestational diabetes mellitus (GDM) based on well-designed studies that have found no association between these agents and congenital malformations. These agents have an efficacy comparable with insulin in their ability to facilitate achievement of targeted levels of glycemic control on all GDM severity levels and in obese patients. Therefore, level of glycemic control achieved, not the mode of therapy is the key to improving outcomes in GDM.

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Department of Obstetrics and Gynecology, St Luke's-Roosevelt Hospital Center, Columbia University, New York, New York

Correspondence: Oded Langer, MD, PhD, Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, 1000 Tenth Avenue, New York, NY 10019. E-mail:

© 2007 by Lippincott Williams & Wilkins.