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Biochemistry in the Diagnosis and Management of Abnormal Early Pregnancy


Clinical Obstetrics and Gynecology: March 2007 - Volume 50 - Issue 1 - p 55-66
doi: 10.1097/GRF.0b013e318030571a
First Trimester Pregnancy Complications

Purpose of Review: To examine the current state of knowledge regarding the biochemical parameters of early pregnancy failure.

Findings: Earlier studies have concentrated on the role of human chorionic gonadotropin and progesterone in early pregnancy failure and recent studies have also explored newer markers such as the inhibins and insulin growth factor binding proteins. Multiparameter models have now been created for the prediction of successful expectant management of early pregnancy failure.

Summary: Examining the role of newer biochemical markers in the early pregnancy failure has led to an improved understanding of the underlying mechanisms and has clinical benefit in the selection of appropriate management for patients.

Sunderland Reproductive Endocrine Research Group, City Hospital Sunderland NHS Foundation Trust, Sunderland, United Kingdom

Correspondence: Maya Chetty, MBBS, Fertility Unit, Sunderland Royal Hospital, Kayll Road, Sunderland, SR4 7TP. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.