January 2018 - Volume 35 - Issue 1

  • Aatif M. Husain, M.D.
  • 0736-0258
  • 1537-1603
  • 6 issues / year
  • Clinical Neurology 153/192
    Neurosciences 220/256
  • 1.337

​​​Abend 1.jpgNicholas S. Abend, MD​ completed medical school and pediatrics residency at the University of Chicago, child neurology residency and pediatric epilepsy/EEG fellowship at the Children's Hospital of Philadelphia, and a Master's degree in Clinical Epidemiology at the University of Pennsylvania.  He is currently an Associate Professor of Neurology and Pediatrics at the University of Pennsylvania and the Children's Hospital of Philadelphia, where is also the Medical Director of the Clinical Neurophysiology Lab.  He is a member of the Council of the American Clinical Neurophysiology Society (ACNS), the current chair of the Critical Care EEG Monitoring Research Consortium, an Associate Scholar in the Center for Epidemiology and Biostatistics at the University of Pennsylvania, and a fellow of the ACNS and the American Epilepsy Society.  He has received the Cosimo Ajmone-Marson Award from the Journal of Clinical Neurophysiology and the Resident Teaching Award from the Department of Neurology at the University of Pennsylvania.  

Abend 2.jpgDr. Abend's NIH-funded research addresses the neuroprotective potential of EEG monitoring and seizure management in critically ill children and neonates.  His studies have demonstrated that electrographic seizures are common in critically ill children with acute encephalopathy, high electrographic seizure  exposures are associated with worse neurobehavioral outcomes even after adjustment for brain injury etiology and critical illness severity, and more rapid electrographic seizure management initiation is associated with higher anti-seizure medication efficacy.  However, continuous EEG monitoring is resource intense.  This led to the question, how much would seizure identification and management have to improve neurobehavioral outcomes to make EEG monitoring a cost effective strategy?  A cost effectiveness analysis indicated that even a small improvement in patient outcomes would make EEG monitoring a cost-effective strategy despite the high initial costs.  Thus, further study is warranted to determine whether optimized electrographic seizure management improves patient outcomes.

Current Issue Highlights