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Nerve Ultrasound, Electrophysiological, and Clinical Changes in Treatment-Naive Chronic Inflammatory Demyelinating Polyneuropathy

A Case Report

Sato, Takeo*; Terasawa, Yuka*; Higa, Hitomi*; Matsuno, Hiromasa*; Arai, Ayumi; Omoto, Shusaku*; Mitsumura, Hidetaka*; Toyoda, Chizuko*; Koike, Haruki; Iguchi, Yasuyuki*

Journal of Clinical Neurophysiology: January 2019 - Volume 36 - Issue 1 - p 82–84
doi: 10.1097/WNP.0000000000000524
Case Report

Summary: We report the case of a 74-year-old woman with treatment-naive chronic inflammatory demyelinating polyneuropathy evaluated by both nerve conduction studies and nerve ultrasound (NUS) before and after initial treatment. Performing both nerve conduction study and NUS before and after initial treatment seems rare for treatment-naive chronic inflammatory demyelinating polyneuropathy. This case yielded two major findings. First, improvement of nerve swelling as evaluated by NUS correlated well with the improvement of neurological symptoms. Second, NUS improvements were seen right after treatment, whereas electrophysiological improvements were not. Nerve ultrasound might thus allow for judgment of curative effects much more immediately and sensitively than nerve conduction study in treatment-naive chronic inflammatory demyelinating polyneuropathy.

Departments of *Neurology and

Radiology, The Jikei University School of Medicine, Tokyo, Japan; and

Department of Neurology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya.

Address correspondence and reprint requests to Takeo Sato, MD, Department of Neurology, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan; e-mail:

The authors have no funding or conflicts of interest to disclose.

© 2019 by the American Clinical Neurophysiology Society