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Lateralized Periodic Discharges

A Literature Review

Lin, Lu; Drislane, Frank W.

Journal of Clinical Neurophysiology: May 2018 - Volume 35 - Issue 3 - p 189–198
doi: 10.1097/WNP.0000000000000448
Invited Review

Summary: The purpose of this article is to provide a comprehensive review of the literature about a particular EEG pattern, lateralized periodic discharges (LPDs), or periodic lateralized epileptiform discharges (PLEDs). The review will discuss the history and terminology of LPDs and provide a detailed summary of the etiologies, pathophysiology, clinical symptoms, and imaging studies related to LPDs. Current controversies about the association of LPDs with seizures and their management will be reviewed. Finally, some unanswered questions and suggestions for future research on LPDs will be discussed.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, U.S.A.

Address correspondence and reprint requests to Frank W. Drislane, MD, Department of Neurology, KS 479, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, U.S.A.; e-mail:

The authors have no funding or conflicts of interest to disclose.

© 2018 by the American Clinical Neurophysiology Society