Review ArticlesAntidepressants Effects on Pain in Parkinson Disease: A Systematic ReviewAnghelescu, Beatrice Ana-Maria BA∗,†; Todoran, Raluca‡; Terroba-Chambi, Cinthia MD, PhD†; Bruno, Veronica MD, MPH∗,†Author Information ∗Department of Clinical Neurosciences, University of Calgary, Calgary, Canada †Hotchkiss Brain Institute, University of Calgary, Calgary, Canada ‡Neuroscience and Mental Health Mental Health Insitute, University of Alberta, Edmonton, Canada Address correspondence and reprint requests to Veronica Bruno, MD, MPH, Department of Clinical Neuroscience, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada; E-mail: [email protected] Funding: The authors have no financial disclosures concerning this manuscript. Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare. B.A.-M.A. and R.T. contributed equally to this project. Author Contributions: B.A.-M.A., R.T., and V.B. conceptualized and designed the initial project of this manuscript. B.A.-M.A., R.T., and V.B. made the final research plan. B.A.-M.A., R.T., C.T.-C., and V.B. ran the statistical analyses and made a definitive interpretation of the findings. B.A.-M.A., R.T., C.T.-C., and V.B. wrote the first version of the manuscript. All authors edited and approved the final version of the manuscript. Clinical Neuropharmacology: 11/12 2021 - Volume 44 - Issue 6 - p 210-215 doi: 10.1097/WNF.0000000000000483 Buy Metrics Abstract Objective Pain in Parkinson disease (PD) is complex as this symptom can be multifactorial in origin because deficits in dopaminergic but also other neurotransmitters are involved. Pain and depression are increasingly recognized to have clinical importance for the quality of life of people living with PD. This systematic review aims to summarize the existing evidence on the potential benefit of using prescribed antidepressants for decreasing or controlling pain associated with PD. Methods PubMed databases were searched for relevant studies using keywords and our exclusion/inclusion criteria and targeting only randomized placebo-controlled trials for antidepressants in PD. Results After screening 108 articles, only 3 focused articles were analyzed. Two of the included studies reported were on nortriptyline and paroxetine antidepressants. Unfortunately, included studies did not align in their outcome measures and did not directly compare the drug groups against each other or the placebo. Therefore, the complex nature of the unaligned outcome measures is inadequate for interpreting the efficacy of antidepressants in treating pain symptoms in PD. The third study focused solely on observing the effects of duloxetine but showed no favorable effects of this drug on pain. Conclusions Prospective studies with a direct comparison of antidepressants and placebo should be conducted, focusing on pain-related scales and questions to understand further the role of antidepressants in treating pain in PD. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.