An Option to Consider for Alternating Hemiplegia of Childhood: Aripiprazole : Clinical Neuropharmacology

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An Option to Consider for Alternating Hemiplegia of Childhood: Aripiprazole

Dundar, Nihal Olgac MD*; Cavusoglu, Dilek MD; Kaplan, Yusuf Cem MD; Hasturk, Mehmet Oytun MD§

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Clinical Neuropharmacology 42(3):p 88-90, 5/6 2019. | DOI: 10.1097/WNF.0000000000000339

Abstract

Alternating hemiplegia of childhood (AHC) is an infrequent neurological disorder characterized by recurrent transient attacks of hemiplegia that last minutes to days and impress either side of the body, dystonic or tonic attacks, and nystagmus. Cognitive or neurological deficits with progressive course are another findings. Epileptic seizures may occur in some patients. We report the medical treatment in a case of AHC in a-12-year-old male patient with convulsions. The patient did not respond to available therapies for AHC, except for aripiprazole. After the initiation of aripiprazole therapy, duration and frequency of hemiplegia episodes were decreased. Also, he is currently seizure-free with topiramate treatment for 3 months. On follow-up, a compound heterozygous ATP1A3 mutation c.868C > T (p.R290C)/c.684 + 1G > A was determined. Aripiprazole may reduce the attacks of AHC, which are resistant to other available therapies.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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