Case ReportsA Case of Buspirone Demonstrating Immediate and Sustained Benefit in a Man With Lifelong Non–Rapid-Eye-Movement ParasomniasMallapareddi, Arun MD, MPH*; Varghese, Ranji MD†‡Author Information *Departments of Family Medicine and †Minnesota Regional Sleep Disorders Center, Neurology/Sleep Medicine, Hennepin Healthcare; and ‡Department of Neurology, University of Minnesota, Minneapolis, MN. Address correspondence and reprint requests to Arun Mallapareddi, MD, MPH, Department of Family Medicine, Whittier Clinic, Hennepin Healthcare, 2810 Nicollet Ave, Minneapolis, MN 55408; E-mail: email@example.com Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare. Clinical Neuropharmacology: 3/4 2019 - Volume 42 - Issue 2 - p 52-54 doi: 10.1097/WNF.0000000000000321 Buy Metrics Abstract Background Non–rapid-eye-movement (NREM) parasomnias are disorders of sleep ranging from confusional arousals to sleepwalking and sleep-related eating disorders. Historically, antidepressants and benzodiazepines were recommended in treatment of NREM parasomnias. In this case report, we are reporting the use of buspirone in a patient with NREM parasomnias, which produced substantial resolution of symptoms. Case Presentation A 38-year-old man presented with confusional arousals and somnambulism. In addition, the patient had significant anxiety with work-related stress. Given the patient's concerns of side effect profile of other medications indicated in NREM parasomnias and the patient's history of anxiety, we started the patient on buspirone. The patient had significant improvement in his symptoms immediately after starting the medication with sustained relief from symptoms. Conclusion Buspirone can be considered an effective alternate treatment option for NREM parasomnias when other medications are not preferred or cannot be prescribed. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.