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Blepharospasm as a Manifestation of Peak of Dose Dyskinesia in Parkinson Disease

Ramírez-Gómez, Carolina C., MD*; Zúñiga-Ramírez, Carlos, MD, MSc; Contartese, María Laura, MD*; Montilla, Verónica, MD*; Gramajo, Jorge, MD; Micheli, Federico, MD, PhD*

doi: 10.1097/WNF.0000000000000316
Original Articles

Objectives The aim of the study was to report 4 patients with Parkinson disease (PD) and On-period blepharospasm (BS).

Methods We analyzed patients with PD and motor fluctuations who developed BS in several different centers in Latin America.

Results Four patients had BS while in the ON periods.

Conclusions Blepharospasm in the On period in patients with PD is extremely uncommon, and our series is the only one to describe such association.

*Parkinson Disease and Movement Disorders Center. Buenos Aires, Argentina;

Movement Disorders and Neurodegenerative Diseases Unit, Hospital Civil de Guadalajara “Fray Antonio Alcalde,” Guadalajara, Mexico; and

Parkinson Disease and Movement Disorders Clinical, Neurosciences Department, Hospital General “San Juan de Dios,” Guatemala City, Guatemala.

Address correspondence and reprint requests to Federico Micheli, MD, PhD, Juncal 1695, 5°J. Buenos Aires, Argentina; E-mail:

Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.

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