*Postgraduate Program in Child and Adolescent Health, School of Medicine, Federal University of Rio Grande do Sul; †Department of Pediatrics, Child Neurology Unit, Hospital de Clínicas de Porto Alegre; ‡Department of Internal Medicine, School of Medicine, Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), §Department of Pharmacology, Institute for Basic Health Sciences, Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), and ∥Department of Pediatrics, Child Neurology Unit, Postgraduate Program in Child and Adolescent Health, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Author contributions: All authors made substantial contribution to the conception and design of the study. J.M., L.O., L.B.R., M.M.M.G., and J.R. worked in case admission and data collection/analysis. L.O., L.B.R., M.M.M.G., and J.R. assisted with data collection/analysis, and R.R. and G.S. with data analysis. All authors participated in drafting the article or revising it for important intellectual content and gave final approval of the version to be published. J.M. and M.M.B. wrote the article. R.S.R., R.R., and G.S. critically reviewed the article. G.S. and R.S.R. take responsibility for the study as a whole.
Conflicts of Interest and Source of Funding: M.M.B., L.O., R.S.R., G.S., and R.R. are inventors in a patent application (WO2013185187 A1) claiming the use of gastrin-releasing peptide for the treatment of neuropsychiatry and neurodevelopmental disorders. J.M., L.B.R., M.M.M.G., and J.R. has no conflict of interest. Financial support was provided by FIPE-HCPA (Fundo de Investimento em Pesquisas e Eventos do Hospital de Clínicas de Porto Alegre) and by the SOAD Foundation (South American Office for Anticancer Drug Development).
Official institution: Hospital de Clínicas de Porto Alegre (HCPA).
Address correspondence and reprint requests to Josemar Marchezan, MD, Department of Pediatrics, Child Neurology Unit, Hospital de Clínicas de Porto Alegre. Ramiro Barcelos, 2350, Porto Alegre, RS CEP 90035-903, Brazil; E-mail: [email protected]
Ethical approval: The study was approved by the HCPA Medial Research Ethics Committee (project number 14-0011).
