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Treating Schizophrenia With the Diuretic Bumetanide: A Case Report

Lemonnier, Eric MD; Lazartigues, Alain MD, PhD; Ben-Ari, Yehezkel PhD

doi: 10.1097/WNF.0000000000000136
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Administration of the diuretic and NKCC1 chloride cotransporter antagonist bumetanide reduces the severity of autism spectrum disorders in children, and this effect is mediated by a reduction of the elevated intracellular chloride concentrations and a reinforcement of GABAergic inhibition (Lemonnier et al Transl Psychiatry. 2012;2:e202; Tyzio et al Science. 2014;343:675–679). Here, we report that this treatment also reduces the severity of symptoms in an adolescent with schizophrenia. Long-term treatment reduced hallucinations significantly, suggesting that this treatment may also be useful to treat schizophrenia. Further clinical trials and experimental studies are warranted to test this hypothesis.

*Centre Expert Autisme Limousin, Limoges; and †Neurochlore c/o Inmed, INSERM U901, Marseilles, France.

Address correspondence and reprint requests to Eric Lemonnier, MD, Centre Expert Autisme Limousin, CHU Limoges, Hopital Le Cluzeau, 23 Avenue Dominique Larrey, 87000 Limoges, France; E-mail: eric.lemonnier@chu-limoges.fr; Yehezkel Ben-Ari, PhD, Neurochlore c/o Inmed, INSERM U901, 163 Route de Luminy, Marseilles 13273, France; E-mail: yehezkel.ben-ari@inserm.fr

Conflicts of Interest and Source of Funding: E.L and Y.B.-A. are founders of Neurochlore a company devoted to develop novel treatments for autism.

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