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Antidepressant-Induced Sleep Bruxism: Prevalence, Incidence, and Related Factors

Uca, Ali Ulvi MD*; Uğuz, Faruk MD; Kozak, Hasan Hüseyin MD*; Gümüş, Haluk MD; Aksoy, Fadime MD; Seyithanoğlu, Abdullah MD*; Kurt, Hatice Güncü MD

doi: 10.1097/WNF.0000000000000108
Original Articles

Objective The relationship between sleep bruxism and antidepressant drugs in patients remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related bruxism and to examine whether antidepressant use is associated with this adverse effect in the patients.

Methods The study sample was gathered from 2 hospitals. A total of 807 patients who met the inclusion criteria were included in the study. The sample was divided into 2 groups: the antidepressant group (n = 506) and the control group (n = 301). Sleep bruxism was established with reports from the study participants on the basis of the International Classification of Sleep Disorders: Diagnosis and Coding Manual Second Edition.

Results The prevalence of bruxism was significantly higher in the antidepressant group (24.3%) than in the control group (15.3%). The incidence of antidepressant-induced bruxism was 14.0%. The antidepressants most associated with bruxism were paroxetine, venlafaxine, and duloxetine. The patients experiencing antidepressant-induced bruxism had higher age compared with those who did not experience this adverse effect.

Conclusions The results of the present study suggest that bruxism is frequently observed in women taking antidepressants and that it seems to be associated with antidepressant use at least in some patients.

Departments of *Neurology and †Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya; and ‡Clinic of Neurology, Manisa Merkezefendi State Hospital, Manisa, Turkey.

Address correspondence and reprint requests to Ali Ulvi Uca, MD, Department of Neurology, Meram Faculty of Medicine, Necmettin Erbakan University, 42080 Meram, Konya, Turkey; E-mail:

Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.

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