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Terazosin for the Treatment of Trauma-Related Nightmares: A Report of 4 Cases

Nirmalani-Gandhy, Anjali MD; Sanchez, Deborah MD, MPH; Catalano, Glenn MD

doi: 10.1097/WNF.0000000000000077
Case Reports

The selective α1-adrenergic antagonist prazosin has been shown in multiple studies to be effective in targeting trauma-related nightmares in posttraumatic stress disorder. There are limited data regarding the effectiveness of another selective α1-adrenergic antagonist terazosin for the treatment of trauma-related nightmares. We present 4 cases in which terazosin was effectively used to treat nightmares as a second-line agent after prazosin failure. Further studies are needed to validate terazosin as an alternative to prazosin for the treatment of posttraumatic stress disorder–related nightmares.

James A. Haley Veterans' Hospital, Tampa, FL.

Address correspondence and reprint requests to Anjali Nirmalani-Gandhy, MD, James A. Haley Veterans' Hospital, 13000 Bruce B. Downs Blvd, 116-A, Tampa, FL 33612; E-mail:

Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.

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