Original ArticlesEffect of Midazolam on Memory During Fiberoptic Gastroscopy Under Conscious SedationHong, Yun Jeong MD*; Jang, Eun Hye MD*; Hwang, Jihye MD*; Roh, Jee Hoon MD, PhD*; Kwon, Miseon PhD*; Lee, Don MD†; Lee, Jae-Hong MD, PhD*Author Information *Department of Neurology, and †Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. Address correspondence and reprint requests to Jae-Hong Lee, MD, PhD, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea; E-mail: email@example.com Conflicts of interest and source of funding: The authors have no conflicts of interest to declare. Clinical Neuropharmacology: March/April 2015 - Volume 38 - Issue 2 - p 47-51 doi: 10.1097/WNF.0000000000000067 Buy Metrics Abstract Objective As the fiberoptic gastroscopy using midazolam is being in widespread use, the exact nature of midazolam on memory should be clarified. We intended to examine whether midazolam causes selective anterograde amnesia and what impact it has on other aspects of memory and general cognitive function. Methods We recruited healthy subjects undergoing fiberoptic gastroscopy under conscious sedation. At baseline, history taking for retrograde amnesia and the Korean version of the Montreal Cognitive Assessment were performed. A man’s name and address were given immediately after intravenous midazolam administration. After gastroscopy, the subjects were asked to recall those items. By the time they had fully recovered consciousness, the same test was repeated along with the Korean version of the Montreal Cognitive Assessment and a test for retrograde amnesia. Results A total of 30 subjects were enrolled in this study. Subjects with high-dose midazolam showed lower scores in the immediate and delayed recall of “a man’s name and address” compared with those with low-dose midazolam. The midazolam dose was inversely correlated with the delayed recall scores of “a man’s name and address.” On full recovery of consciousness, the subjects did not exhibit any of anterograde or retrograde amnesia. Conclusions These findings suggest that midazolam causes transient selective anterograde amnesia in a dose-dependent manner. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.