Case ReportsA Case of Abulia, Status/Post Right Middle Cerebral Artery Territory Infarct, Treated Successfully With OlanzapineSpiegel, David R. MD; Chatterjee, Aparna BSAuthor Information Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, Norfolk, VA. Address correspondence and reprint requests to David R. Spiegel, MD, Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23507; E-mail: firstname.lastname@example.org Conflicts of Interest and Source of Funding: Dr Spiegel is on the Speaker’s Bureau for Forest Pharmaceuticals. For the remaining author, none were declared. Clinical Neuropharmacology: November/December 2014 - Volume 37 - Issue 6 - p 186-189 doi: 10.1097/WNF.0000000000000053 Buy Metrics Abstract Abulia refers to a pathological deficit of willpower. Disruption of frontal-subcortical-mesolimbic circuits caused by lesions in certain central nervous system structures has been associated with abulia. Given the neurobiological link between the dopaminergic reward system and the psychological phenomenon of motivation, it has been speculated that modulating dopaminergic neurotransmission will potentially alter the clinical presentation of abulia. We present a case of abulia S/P right middle cerebral artery, treated successfully with olanzapine. © 2014 by Lippincott Williams & Wilkins.