Case ReportsAmbroxol-Induced Focal Epileptic SeizureLapenta, Leonardo MD, PhD; Morano, Alessandra MD; Fattouch, Jinane MD, PhD; Casciato, Sara MD; Fanella, Martina MD; Giallonardo, Anna Teresa MD; Di Bonaventura, Carlo MD, PhDAuthor Information Epilepsy Unit, Department of Neurological Sciences, “Sapienza” University of Rome, Rome, Italy. Address correspondence and reprint requests to Carlo Di Bonaventura, MD, PhD, Department of Neurological Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Viale dell’Università 30, 00185-Rome, Italy; E-mail address: firstname.lastname@example.org Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare. Clinical Neuropharmacology: May/June 2014 - Volume 37 - Issue 3 - p 84-87 doi: 10.1097/WNF.0000000000000031 Buy Metrics Abstract It is well known that in epileptic patients some compounds and different drugs used for the treatment of comorbidities can facilitate or provoke seizures, this evidence regarding a wide spectrum of pharmacological categories. The potential facilitating factors usually include direct toxic effects or pharmacological interactions of either active ingredients or excipients. We report the case of a patient with drug-resistant epilepsy who experienced focal epileptic seizures, easily and constantly reproducible, after each administration of a cough syrup. This is, to our knowledge, the first electroencephalogram-documented case of focal epileptic seizures induced by cough syrup containing ambroxol as active ingredient. © 2014 by Lippincott Williams & Wilkins.