Case ReportsSingle-Dose Oral Lacosamide in Refractory Simple Partial Status Epilepticus: Case Report and ReviewHawkes, Maximiliano A. MD; Fernández Suárez, Marcos MD; Ugarnes, Gabriela MD,; D’Giano, Carlos MDAuthor Information *Neurology Department, and †Epilepsy Programme, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina. Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare. Address correspondence and reprint requests to Maximiliano A. Hawkes, MD, Montañeses 2325 Ciudad Autónoma de Buenos Aires, Buenos Aires, (C1428AQK), Argentina; E-mail: firstname.lastname@example.org Clinical Neuropharmacology: July/August 2013 - Volume 36 - Issue 4 - p 138-140 doi: 10.1097/WNF.0b013e31829b21ba Buy Metrics Abstract Objectives This study aimed to present 2 patients with simple partial refractory status epilepticus (RSE) treated with a single oral lacosamide (LCM) dose and to review the literature on this topic. Method A retrospective description of 2 patients with simple partial RSE treated with 300 mg of LCM per os (PO) and a literature review were done. Results Both patients responded to single-dose oral LCM treatment with seizure cessation after 30 minutes. Conclusions This is the first report on successful treatment of simple partial RSE with a single-dose of LCM PO. Oral LCM might represent an option for treatment of patients presenting with simple partial RSE. Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.