Case ReportsLamotrigine Abolished Aggression in a Patient With Treatment-Resistant Posttraumatic Stress DisorderKozarić-Kovačić, Dragica MD, PhD; Eterović, Marija MD Author Information Department of Psychiatry, University Hospital Dubrava, Referral Centre for Stress Related Disorders of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia. Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare. Address correspondence and reprint requests to Dragica Kozarić-Kovačić, MD, PhD, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia; E-mail: [email protected] Clinical Neuropharmacology: May/June 2013 - Volume 36 - Issue 3 - p 94-95 doi: 10.1097/WNF.0b013e318288a7d3 Buy Metrics Abstract Lamotrigine is an antiepileptic drug with broad spectrum of actions, also approved for the treatment of bipolar disorder. Growing number of reports document the antiaggressive effect of lamotrigine in various psychiatric diseases. However, there has been only 1 study in the literature investigating the role of lamotrigine in posttraumatic stress disorder (PTSD), but its antiaggressive aspect was not observed. Although aggression is commonly associated with PTSD, there is paucity of data considering its management. We report a case of a patient with treatment-resistant PTSD, whose aggressive outbursts dominated his clinical picture and which were greatly improved after introducing lamotrigine in therapy. Our case suggests that lamotrigine may be useful in treating aggression and aggression-related symptoms in PTSD. © 2013 by Lippincott Williams & Wilkins.