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Cetirizine-Associated Delusions and Depression in an 18-Year-Old Woman

Garden, Benjamin C.; Francois, Dimitry MD

doi: 10.1097/WNF.0b013e318290b9b2
Case Reports
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Introduction Cetirizine is a second-generation H1 histamine receptor antagonist that is commonly used for symptomatic relief of hay fever and other allergies and can be combined with pseudoephedrine hydrochloride, a decongestant. The most common adverse effects include headache, nausea, nasopharyngitis, vomiting, and coughing.

Objective To report on an adolescent 18-year-old woman who developed delusional thinking and depression after starting treatment with cetirizine.

Case Report We report on an adolescent 18-year-old woman who developed delusional thinking and depression after starting treatment with cetirizine. Once cetirizine was discontinued, the patient returned to her clinical baseline.

Conclusions Physicians need to be aware of the potential psychiatric adverse effects associated with cetirizine.

Weill Cornell Medical College, New York Presbyterian Hospital, White Plains, NY

Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare.

Address correspondence and reprint requests to Dimitry Francois, MD, 21 Bloomingdale Rd, White Plains, NY 10605; E-mail: dif9013@med.cornell.edu

© 2013 by Lippincott Williams & Wilkins.