Case ReportsLamotrigine Augmentation in Premenstrual Dysphoric Disorder A Case ReportSepede, Gianna MD, PhD; Martinotti, Giovanni MD, PhD; Gambi, Francesco MD, PhD; Salerno, Rosa Maria MD; Di Giannantonio, Massimo MD Author Information Department of Neuroscience and Imaging, Chair of Psychiatry, “G d’Annunzio” University of Chieti, Chieti, Italy. Conflicts of Interest and Source of Funding: The authors have no conflicts of interest to declare. Funding for this study was provided by the Department of Neuroscience and Imaging, “G. D’Annunzio” University of Chieti, Italy. No pharmaceutical and industry support was used in this study. All authors contributed to the study and have approved the final manuscript. The patient gave her written informed consent for data publication. Address correspondence and reprint requests to Gianna Sepede, MD, PhD, Department of Neuroscience and Imaging, ITAB—Institute for Advanced Biomedical Technologies, University “G. D’Annunzio” of Chieti, Via dei Vestini 33, 66013 Chieti Scalo (CH), Italy; E-mail: [email protected]; [email protected] Clinical Neuropharmacology: January/February 2013 - Volume 36 - Issue 1 - p 31-33 doi: 10.1097/WNF.0b013e318279ee1f Buy Metrics Abstract Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome, characterized by depressive, anxious, and somatic symptoms, associated to a significant reduction in social functioning and quality of life. Although selective serotonin reuptake inhibitors (SSRIs) and oral contraceptives show a substantial effectiveness in PMDD, a wide percentage of women affected by PMDD do not respond to those first-line treatments. We present the case of a 42-year-old woman, affected by a disabling form of PMDD, who partially responded to an SSRI treatment and significantly improved after an add-on therapy with lamotrigine. We therefore suggest that lamotrigine may be an efficacious and safe augmentation strategy in severe PMDD cases showing unsatisfactory or partial response to SSRI treatments. © 2013 Lippincott Williams & Wilkins, Inc.