Case ReportsPregabalin Resolves Refractory Aparathyroid Paroxysmal Kinesigenic ChoreoathetosisBaek, William S. MDAuthor Information Desai Neurology Group, Upland, CA. Conflicts of Interest and Source of Funding: This was a nonfunded study. The author has no conflicts of interest to declare. Address correspondence and reprint requests to William S. Baek, MD, Desai Neurology Group, 630 N 13th Ave Suite B, Upland, CA 91786; E-mail: William_S_Baek@hotmail.com Clinical Neuropharmacology: July/August 2012 - Volume 35 - Issue 4 - p 203 doi: 10.1097/WNF.0b013e31825bd3d7 Buy Metrics Abstract Objective The objective of this study was to determine the potential efficacy of pregabalin as treatment for aparathyroid paroxysmal kinesigenic choreoathetosis. Method This was a case report. Results A 54-year-old white woman presented with a 20-year history of choreoathetoid and ballistic movements, which had developed as the result of parathyroidectomy. On examination, she demonstrated classic choreoathetoid movements with gait ataxia. Cognition was normal. Parathyroid hormone levels were near-absent with the rest of her workup being normal. Pregabalin 100 mg 3 times daily decreased her movements based on the Unified Huntington’s Disease Rating Scale from 46 to 0. Conclusions It is unclear how pregabalin, which acts on the calcium channel α(2) δ-1 subunit, can help aparathyroid paroxysmal kinesigenic choreoathetosis. Further studies are required to see if pregabalin normalizes calcium metabolism in the basal ganglia. © 2012 Lippincott Williams & Wilkins, Inc.