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Combined Beneficial Effect of Rasagiline on Motor Function and Depression in De Novo PD

Korchounov, Alexei MD*; Winter, Yaroslav MD; Rössy, Wolfgang MD

doi: 10.1097/WNF.0b013e31823b1da8
Original Articles

Objectives To investigate prokinetic and antidepressive effects of rasagiline in de novo Parkinson disease (PD).

Materials and Methods Patients with newly diagnosed PD with comorbid untreated depression were randomly assigned to rasagiline monotherapy 1 or 2 mg/d. Unified Parkinson’s Disease Rating Scale Part 2 (Activity of Daily Living) and Part 3 (Motor Function), and Hamilton Depression Rating Scale (HDRS) assessments were carried out by a blinded investigator in each patient at baseline and after 8 weeks of rasagiline treatment.

Results Both groups showed equal motor improvement at the end point. The improvements of HDRS score and activity of daily living were significantly more pronounced with rasagiline, 2 mg/d, than rasagiline, 1 mg/d (P = 0.0002). The treatment with rasagiline, 2 mg/d, improved symptoms in all HDRS core depression symptoms and specifically those not considered to be influenced by motor function: mood, guilt, psychic anxiety, and hypochondria.

Conclusion Our results suggest that antidepressive effect seen in higher dosage of rasagiline may be not related to the motor improvement.

*Parkinson Department, Marienhospital Kevelaer, Kevelaer, Germany; †Department of Neurology, Philips University of Marburg, Marburg, Germany; and ‡Clinic for Neurology Bad Schönborn, Bad Schönborn, Germany.

Conflicts of Interest and Source of Funding: No author has received compensation from pharmaceutical companies for the present study.

The authors have nothing to declare.

Address correspondence and reprint requests to Alexei Korchounov, MD, Parkinson Department, Marienhospital Kevelaer, Basilika Str. 55, 47612 Kevelaer, Germany; E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.