Original ArticlesTreatment of Psychogenic Polydipsia With Acetazolamide: A Report of 5 CasesTakagi, Shunsuke MD; Watanabe, Yutaka MD, PhD; Imaoka, Takefumi MD; Sakata, Masuhiro MD; Watanabe, Masako MD, PhDAuthor Information Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan. There was no sources of support or external funding for this study. Address correspondence and reprint requests to Shunsuke Takagi, MD, Department of Psychiatry, National Center of Neurology and Psychiatry, Ogawahigashi 4-1-1, Kodaira, Tokyo 187-8553, Japan; E-mail: firstname.lastname@example.org Clinical Neuropharmacology: January-February 2011 - Volume 34 - Issue 1 - p 5-7 doi: 10.1097/WNF.0b013e318205070b Buy Metrics Abstract Objective: Psychogenic polydipsia occurs frequently in patients with chronic psychiatric illness and is often unmanageable. We herein report 5 patients in whom acetazolamide was trialed for this symptom. Methods: We encountered a case in which polydipsia improved with incidental administration of acetazolamide. We then used this treatment for 4 additional cases of treatment-resistant psychogenic polydipsia, some of which were accompanied by hyponatremia. Results: Acetazolamide improved polydipsia and/or hyponatremia in 4 of the 5 cases. This treatment was well tolerated and allowed 3 of the patients to permanently leave isolation. Conclusion: Acetazolamide appears to have a beneficial effect in psychogenic polydipsia. © 2011 Lippincott Williams & Wilkins, Inc.