Original ArticlesLamotrigine Administration in Panic Disorder With AgoraphobiaMasdrakis, Vasilios G. MD; Papadimitriou, George N. MD; Oulis, Panagiotis MD, PhD Author Information Eginition Hospital, 1st Department of Psychiatry, Athens University Medical School, Athens, Greece. Address correspondence and reprint requests to Vasilios G. Masdrakis, MD, Eginition Hospital, 74 Vas. Sofias Ave, Athens 11528, Greece; E-mail: [email protected] The authors have no conflict of interest with any commercial or other associations in connection with the submitted article. Clinical Neuropharmacology: May 2010 - Volume 33 - Issue 3 - p 126-128 doi: 10.1097/WNF.0b013e3181d4c1f6 Buy Metrics Abstract Several anticonvulsants, although as yet not lamotrigine (LTG), have been found useful in the treatment of panic disorder with (PDA) or without agoraphobia. We administered LTG (200 mg/d) to 4 outpatients with PDA, as an augmentation therapy (3 patients with chronic and severe agoraphobia) or monotherapy (1 drug-naive patient with first-onset PDA) in a 14-week trial. The patient under LTG monotherapy improved significantly, whereas PDA symptoms in 2 of the other patients improved to some extent. © 2010 Lippincott Williams & Wilkins, Inc.