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Levetiracetam Improves Intention Tremor in Fragile X-Associated Tremor/Ataxia Syndrome

Saponara, Riccardo MD*; Greco, Salvatore MD*; Proto, Giuliana MD*; Trubia, Teresa MD*; Domina, Elisabetta MD

doi: 10.1097/WNF.0b013e31816a48e2
Case Reports

Fragile X-associated tremor/ataxia syndrome is a recently discovered disorder affecting more of one third of older adult male carriers of premutation alleles of fragile X mental retardation 1 (FMR1 gene). There is no established treatment.

The 66-year-old right-handed grandfather of a boy with fragile X syndrome, a carrier of premutation alleles of FMR1 gene, developed an action tremor in his right hand when writing. His writing became large and completely illegible. Administration of levetiracetam was associated with subjective and objective improvement, and handwriting became possible again. Levetiracetam was well tolerated, and no adverse effects were reported.

*Neurological Unit Private Hospital "Villa Mauritius" Siracusa; and the †Neurorehabilitation Unit "ODA" Catania, Italy.

Address correspondence and reprint requests to Riccardo Saponara, MD, Unità Funzionale di Neurologia, Villa Mauritius, via Francofonte, 5, I-96100 Siracusa, Italy; E-mail:

© 2009 Lippincott Williams & Wilkins, Inc.