Case ReportSuccessful Treatment of Trigeminal Neuralgia With MilnacipranIto, Mikiko DDS, PhD*; Yoshida, Keizo MD, PhD†; Kimura, Hiroyuki MD†; Ozaki, Norio MD, PhD†; Kurita, Kenichi DDS, PhD*Author Information From the *First Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, and the †Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. Reprints: Keizo Yoshida, MD, PhD, Department of Psychiatry, Nagoya University Graduate School of Medicine. 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan; E-mail: firstname.lastname@example.org. Clinical Neuropharmacology: May-June 2007 - Volume 30 - Issue 3 - p 183-185 doi: 10.1097/wnf.0b013e31803bb3da Buy Metrics Abstract Paroxysmal pain in a 64-year-old woman diagnosed with trigeminal neuralgia disappeared with the administration of carbamazepine, but carbamazepine had to be discontinued because of intolerable lassitude and liver dysfunction. Afterward, the paroxysmal pain reoccurred, and depressive symptoms appeared. Milnacipran was then administered at a dosage of 50 mg/d for 2 months, and the paroxysmal pain and depression disappeared completely. Carbamazepine is the drug of first choice for trigeminal neuralgia, but the present results suggest that milnacipran is worth investigating for patients who do not respond to carbamazepine, who cannot stay on carbamazepine because of side effects, and who exhibit depressive symptoms. © 2007 Lippincott Williams & Wilkins, Inc.