Case ReportsLamotrigine Serum Concentrations Throughout the Menstrual Cycle-A Study of 2 CasesReimers, Arne MD*†; Brodtkorb, Eylert MD, PhD†‡; Helde, Grethe†; Spigset, Olav MD, PhD* Author Information *Department of Clinical Pharmacology, St Olavs University Hospital, Trondheim, Norway; †Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; and ‡Department of Neurology and Clinical Neurophysiology, St Olavs Hospital, Trondheim, Norway. Address correspondence and reprint requests to Arne Reimers, MD, Department of Clinical Pharmacology, St Olavs University Hospital, 7006 Trondheim, Norway; E-mail: [email protected] Clinical Neuropharmacology: May 2006 - Volume 29 - Issue 3 - p 160-162 doi: 10.1097/01.WNF.0000220820.78854.3F Buy Metrics Abstract Objectives: To measure the serum concentrations of lamotrigine throughout a complete menstrual cycle. Methods: Serum concentrations of lamotrigine, estradiol, and progestogen throughout a menstrual cycle were measured in 2 young women not using hormonal contraception. Results and Conclusions: The physiological hormonal fluctuations during an ovulatory cycle were not associated with clinically relevant changes in lamotrigine serum concentrations. © 2006 Lippincott Williams & Wilkins, Inc.