Case ReportRemarkable Effect of Selegiline (L-Deprenyl), a Selective Monoamine Oxidase Type-B Inhibitor, in a Patient With Severe Refractory Depression: A Case ReportHiguchi, Hisashi*; Kamata, Mitsuhiro†; Sugawara, Yuka*; Yoshida, Keizo‡Author Information From *Omagari City Hospital, Omagari; the †Department of Neuro-Psychiatry, Yuri Kumiai General Hospital, Honjyo; and the ‡Department of Psychiatry, Nagoya University Graduate School of Medicine, Japan. Reprints: Hisashi Higuchi, Omagari City Hospital, Aza-sekihigashi 210, Iida, Omagari 014-0067, Japan (e-mail: firstname.lastname@example.org). Clinical Neuropharmacology: July-August 2005 - Volume 28 - Issue 4 - p 191-192 doi: 10.1097/01.wnf.0000171248.89726.2f Buy Metrics Abstract A 34-year-old man presented with severe refractory depression. He had failed to respond to various antidepressants, augmentation therapy with lithium carbonate, and modified electroconvulsive therapy. Switching from amoxapine 150 mg/day to selegiline 7.5 mg/day, a selective monoamine oxidase type-B inhibitor, produced a dramatic reduction in hypobulia and lassitude, leading to a complete remission of all depressive symptoms. The patient reverted to his former position at work after an interval of approximately 3 years. Although the biologic basis of the antidepressant effect of selegiline in this patient is unknown, it is suggested that the enhancement of dopaminergic neurotransmission or elevation of brain-derived neurotrophic factor levels in the brain by administration of selegiline is involved in the recovery of this patient from severe refractory depression. This report indicates the antidepressant effect of selegiline in a refractory depressed patient. © 2005 Lippincott Williams & Wilkins, Inc.