Original ArticleBotulinum Toxin and Intractable Trigeminal NeuralgiaTürk, Ülkü*; Ilhan, Selen MD*; Alp, Recep MD*; Sur, Haydar†Author Information From the *Department of Neurology, Dr. Lütfi Kirdar Kartal Research and Education Hospital; †Health Education Faculty, Marmara University. Reprints: Dr. Lűtfi Kirdar Kartal, Research and Education Hospital, Department of Neurology, 34865 Cevizli-Kartal, Istanbul, Turkey (e-mail: email@example.com). Presented as a poster at the 2004 EFNS. 8th Congress of the European Federation of Neurological Societies, Paris, France, September 4-7, 2004. Clinical Neuropharmacology: July-August 2005 - Volume 28 - Issue 4 - p 161-162 doi: 10.1097/01.wnf.0000172497.24770.b0 Buy Metrics Abstract The effects of botulinum toxin have been demonstrated in pain syndromes such as migraine, tension headache, and postherpetic neuralgia. With this background data in hand, the authors planned a randomized, open-ended study to investigate the efficacy of botulinum injections in cases of refractory trigeminal neuralgia. In 8 patients with trigeminal neuralgia, 100 U botulinum toxin was injected into the region of the zygomatic arch. The results of their statistical analyses demonstrated that the medication can be effective in treating trigeminal neuralgia. The patients did not develop any significant adverse effects. Botulinum toxin can be used in the treatment of refractory trigeminal neuralgia. © 2005 Lippincott Williams & Wilkins, Inc.