Original ArticlesMotor Complications in Parkinson Disease:: A Prospective Follow-Up StudyGarcía Ruiz, Pedrox J MD*; Meseguer, Elena MD*; Del Val, Javier MD†; Vázquez, Ana MD*; Bernardos, Vicenta Sanchez RN*; Vázquez, Antonio MD†Author Information From the *Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain; and †Department of Neurology, Hospital Clinico de San Carlos, Madrid, Spain. Reprints: Pedro J. García Ruiz, Department of Neurology, Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid 28040, Spain (e-mail: firstname.lastname@example.org). Clinical Neuropharmacology: March/April 2004 - Volume 27 - Issue 2 - p 49-52 Buy Abstract Currently, Parkinson disease (PD) can be symptomatically controlled with standard treatments; however, after a few years this response typically declines. The authors carried out a prospective practice-based study to evaluate the evolution and motor complications during the first 5 years in 59 de novo PD patients. They observed a significant improvement in UPDRS scores during the first year, then the UPDRS mean score declined progressively, especially after the third year (UPDRS score at baseline, 27 points; year 1, 19 points; year 2, 20.3 points; year 3, 22.6 points; year 4, 24.9 points; year 5, 29.5 points). Motor fluctuations, dyskinesias, and freezing also increased after year 3 from 10%, 16%, and 8% respectively to 35%, 32%, and 27% at year 5. At 5 years, 50% of patients (30 of 59) still had UPDRS scores better or equal to baseline, and 44% (26 of 59) had no motor complications. This latter group represented 38% of those subjects initially treated with levodopa and 52% initially treated with other agents. © 2004 Lippincott Williams & Wilkins, Inc.