Case ReportsClozapine Treatment in Oromandibular DystoniaHanagasi, Hasmet A. MD; Bilgic, Basar MD; Gurvit, Hakan MD; Emre, Murat MDAuthor Information From Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul, Turkey Reprints: Hasmet A. Hanagasi MD Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Capa/Istanbul 34390 Turkey (e-mail: email@example.com). Clinical Neuropharmacology: March/April 2004 - Volume 27 - Issue 2 - p 84-86 Buy Abstract Oromandibular dystonia (OMD) is a form of focal dystonias, which can be associated with substantial disability and is frequently refractory to all antidystonic therapies. Clozapine is a dibenzodiazepin derivative atypical neuroleptic that has been reported to be effective in the treatment of primary or symptomatic dystonia. We report here two patients with severe OMD refractory to other antidystonic therapies, who had substantial improvement with clozapine. We suggest that clozapine should be considered in patients with OMD who fail to response to other treatments. © 2004 Lippincott Williams & Wilkins, Inc.