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Waiting for ON: A Major Problem in Patients With Parkinson Disease and ON/OFF Motor Fluctuations

Merims, Doron; Djaldetti, Ruth; Melamed, Eldad

ORIGINAL ARTICLES
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The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations: time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.

Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva; and Sackler Faculty of Medicine, Tel Aviv University, Israel

Supported in part by the National Parkinson Foundation, USA, and the Norma and Alan Aufzien Chair for Research in Parkinson's Disease, Tel Aviv University, Israel.

Address correspondence and reprint requests to Prof. Eldad Melamed, Professor and Chairman, Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel; e-mail: emelamed@clalit.org.il.

© 2003 Lippincott Williams & Wilkins, Inc.