BRIEF REPORTSEffectiveness of Gorei-san (TJ-17) for Treatment of SSRI-Induced Nausea and Dyspepsia: Preliminary ObservationsYamada, Kazuo*; Yagi, Gohei†; Kanba, Shigenobu*Author Information *Departments of Neuropsychiatry and Clinical Ethics, University of Yamanashi, Faculty of Medicine, Yamanashi; and †Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Supported by funding from Tsumura & Co., Tokyo Japan. Address correspondence and reprint requests to Dr. Kazuo Yamada, Departments of Neuropsychiatry and Clinical Ethics, University of Yamanashi, Faculty of Medicine, 1110 Shimogato, Tamaho-cho, Yamanashi 409-3898, Japan; email: firstname.lastname@example.org Clinical Neuropharmacology: May-June 2003 - Volume 26 - Issue 3 - p 112-114 Buy Abstract Selective serotonin reuptake inhibitors (SSRIs) are apt to cause gastrointestinal adverse events such as nausea and dyspepsia. Gorei-san (TJ-17), which is composed of five herbs (Alismatis rhizoma, Atractylodis lanceae rhizoma, Polyporus, Hoelen, and Cinnamomi cortex), is a Japanese herbal medicine that has been used to treat nausea, dry mouth, edema, headache, and dizziness. The authors investigated the efficacy of TJ-17 for patients who experienced nausea or dyspepsia induced by SSRIs. Twenty outpatients who experienced nausea or dyspepsia induced by SSRIs were recruited for the study. Seventeen patients were female, three were male, and patient age ranged from 21 to 74 years (49.8 ± 17.0 years). TJ-17 was added to the previous regimen. Nausea and dyspepsia disappeared completely in nine patients, decreased in four patients, decreased slightly in two patients, and did not change in five patients. No adverse events were associated with the addition of TJ-17 in any patient. © 2003 Lippincott Williams & Wilkins, Inc.