Original ArticlesWeight and Blood Pressure Change During Clozapine TreatmentBaymiller, Scott P.; Ball, Patricia; McMahon, Robert P.; Buchanan, Robert W.Author Information Maryland Psychiatric Research Center Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA Address correspondence and reprint requests to Robert W. Buchanan, M.D., Maryland Psychiatric Research Center, P.O. Box 21247 Baltimore, MD 21228, USA. E-mail: firstname.lastname@example.org. Clinical Neuropharmacology: July-August 2002 - Volume 25 - Issue 4 - p 202-206 Buy Abstract We examined whether clozapine-related weight gain is associated with an increase in mean arterial blood pressure. Weight gain and mean arterial blood pressure changes were assessed in 61 outpatients with schizophrenia who were randomly assigned to either clozapine or haloperidol in a 10-week parallel group, double-blind study and in 55 patients who chose to continue to receive clozapine in a subsequent 1-year open-label prospective study. Clozapine treatment was associated with significant weight gain in the double blind and open-label trials. Haloperidol treatment was not associated with significant weight gain. Neither clozapine nor haloperidol treatment were associated with significant changes in mean arterial blood pressure. There were no significant correlations between weight gain and mean arterial blood pressure change with either medication. Although clozapine treatment is associated with weight gain, the correlation between this weight gain and increases in arterial blood pressure during the first year of treatment appears to be low. © 2002 Lippincott Williams & Wilkins, Inc.